Faculty Collaboration Database

Airway responses to esophageal acidification. Am J Physiol Regul Integr Comp Physiol 2008 Jan;294(1):R211-9

Date

10/12/2007

Pubmed ID

17928508

DOI

10.1152/ajpregu.00394.2007

Scopus ID

2-s2.0-38149056361 (requires institutional sign-in at Scopus site)   30 Citations

Abstract

The effects of esophageal acidification on airway function are unclear. Some have found that the esophageal acidification causes a small increase in airway resistance, but this change is too small to cause significant symptoms. The aims of this study were to investigate the effects of esophageal acidification on multiple measures of airway function in chloralose-anesthetized cats. The esophagus was cannulated and perfused with either 0.1 M PBS or 0.1 N HCl at 1 ml/min as the following parameters were quantified in separate experiments: diameter of bronchi (n = 5), tracheal mucociliary transport rate (n = 4), tracheobronchial mucus secretion (n = 7), and lung function (n = 6). We found that esophageal acidification for 10-30 min decreased bronchial diameters primarily of the smaller low-resistance airways (10-22%, P < 0.05), decreased tracheal mucociliary transport (53%, 8.7 +/- 2.4 vs. 4.1 +/- 1.3 mm/min, P < 0.05), increased tracheobronchial mucus secretion (147%, 3.4 +/- 0.7 vs. 8.4 +/- 2.6 mg/10 min, P < 0.05), and caused no change in total lung resistance or dynamic compliance (P > 0.05). Considering that tracheal mucociliary transport rate is governed in part by mucus secretion, we concluded that the primary airway response to esophageal acidification observed is increased mucus secretion. Airway constriction may act to assist in rapid secretion of mucus and to increase the effectiveness of coughing while not affecting lung resistance or compliance. Given the buffering capabilities of mucus, esophageal acidification activates appropriate physiological responses that may act to neutralize gastroesophageal reflux that reaches the larynx, pharynx, or lower airways.

Author List

Lang IM, Haworth ST, Medda BK, Roerig DL, Forster HV, Shaker R

Authors

Hubert V. Forster PhD Professor in the Physiology department at Medical College of Wisconsin
Ivan M. Lang DVM, PhD Adjunct Professor in the Medicine department at Medical College of Wisconsin
Bidyut K. Medda PhD Associate Professor in the Medicine department at Medical College of Wisconsin
Reza Shaker MD Assoc Provost, Sr Assoc Dean, Ctr Dir, Chief, Prof in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Airway Resistance
Animals
Bronchi
Cats
Disease Models, Animal
Esophagus
Female
Gastroesophageal Reflux
Hydrochloric Acid
Hydrogen-Ion Concentration
Male
Mucociliary Clearance
Mucus
Respiratory System