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A Case of Necrotizing Epiglottitis Due to Nontoxigenic Corynebacterium diphtheriae. Pediatrics 2015 Jul;136(1):e242-5



Pubmed ID




Scopus ID

2-s2.0-84934289025   9 Citations


Diphtheria is a rare cause of infection in highly vaccinated populations and may not be recognized by modern clinicians. Infections by nontoxigenic Corynebacterium diphtheriae are emerging. We report the first case of necrotizing epiglottitis secondary to nontoxigenic C diphtheriae. A fully vaccinated child developed fever, poor oral intake, and sore throat and was found to have necrotizing epiglottitis. Necrotizing epiglottitis predominantly occurs in the immunocompromised host. Laboratory evaluation revealed pancytopenia, and bone marrow biopsy was diagnostic for acute lymphoblastic leukemia. Clinicians should be aware of aggressive infections that identify immunocompromised patients. This case highlights the features of a reemerging pathogen, C diphtheriae.

Author List

Lake JA, Ehrhardt MJ, Suchi M, Chun RH, Willoughby RE


Robert H. Chun MD Associate Professor in the Otolaryngology department at Medical College of Wisconsin
Mariko Suchi MD, PhD Associate Professor in the Pathology department at Medical College of Wisconsin
Rodney E. Willoughby MD Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Child, Preschool
Corynebacterium Infections
Corynebacterium diphtheriae
Immunocompromised Host
Microbial Sensitivity Tests
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a