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Fatigue, sleep-wake disturbances, and quality of life in adolescents receiving chemotherapy. J Pediatr Hematol Oncol 2011 Jan;33(1):e17-25

Date

11/11/2010

Pubmed ID

21063224

DOI

10.1097/MPH.0b013e3181f46a46

Scopus ID

2-s2.0-78650783408   57 Citations

Abstract

BACKGROUND: Adolescents with cancer experience distressing physical and psychosocial symptoms, especially during treatment. Fatigue and sleep disturbances commonly affect adolescents' quality of life, but little is known about how adolescents experience these symptoms during an early month of chemotherapy. This study measured fatigue, sleep disturbances, and quality of life in 20 adolescents over 1 month while they were receiving chemotherapy.

METHODS: Multidimensional fatigue and quality of life were measured weekly with modules from the PedsQL Measurement Model, and sleep disturbances were measured with the General Sleep Disturbance Scale.

RESULTS: Adolescents experienced increased severity of fatigue and sleep disturbances during the week after treatment. Common sleep-wake problems included daytime sleepiness, decreased alertness, and poor sleep quality. Fatigue and sleep-wake disturbances were related symptoms, and both symptoms were associated with various domains of quality of life.

CONCLUSIONS: Fatigue and sleep-wake disturbances are significant problems for adolescents receiving chemotherapy and negatively affect the quality of life. Clinicians should routinely screen adolescent patients for fatigue and sleep disturbances and intervene to minimize their impact using pharmacologic and nonpharmacologic strategies.

Author List

Erickson JM, Beck SL, Christian BR, Dudley W, Hollen PJ, Albritton KA, Sennett M, Dillon RL, Godder K

Author

Jeanne M. Erickson PhD, RN Associate Professor in the College of Nursing department at University of Wisconsin - Milwaukee




MESH terms used to index this publication - Major topics in bold

Adolescent
Antineoplastic Combined Chemotherapy Protocols
Child
Fatigue
Female
Humans
Male
Neoplasms
Quality of Life
Sleep Wake Disorders
Young Adult