Who is the best alternative allotransplant donor? Bone Marrow Transplant 2015 Jun;50 Suppl 2(0 2):S40-2
Date
06/04/2015Pubmed ID
26039206Pubmed Central ID
PMC4520408DOI
10.1038/bmt.2015.94Scopus ID
2-s2.0-84930420699 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
Assuming that most physicians will chose an HLA-identical sibling as the best allotransplant donor, the question arises who is the best alternative donor when an HLA-identical sibling is unavailable? The most commonly used alternative donors are HLA-identical or -mismatched unrelated donors, HLA-matched or -mismatched umbilical cord blood donor or a related, HLA-haplotype-matched related donors. Each alternative donor option has advantages and disadvantages. We discuss selected aspects of these issues based on data from randomized clinical trials and observational databases. However, because there are limited data to address specific clinical settings, quantification of expert opinion is sometimes needed.
Author List
Gale RP, Eapen MAuthor
Mary Eapen MBBS, DCh, MRCPI, MS Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Allografts
Cord Blood Stem Cell Transplantation
Databases, Factual
Donor Selection
Female
HLA Antigens
Histocompatibility Testing
Humans
Male
Middle Aged
Randomized Controlled Trials as Topic
Siblings
Unrelated Donors
