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Severity of spinal cord injury influences diffusion tensor imaging of the brain. J Magn Reson Imaging 2016 Jan;43(1):63-74



Pubmed ID




Scopus ID

2-s2.0-84955640260   5 Citations


BACKGROUND: The purpose of this study was to determine whether DTI changes in the brain induced by a thoracic spinal cord injury are sensitive to varying severity of spinal contusion in rats.

METHODS: A control, mild, moderate, or severe contusion injury was administered over the eighth thoracic vertebral level in 32 Sprague-Dawley rats. At 11 weeks postinjury, ex vivo DTI of the brain was performed on a 9.4T Bruker scanner using a pulsed gradient spin-echo sequence.

RESULTS: Mean water diffusion in the internal capsule regions of the brain and pyramid locations of the brainstem were correlated with motor function (r(2) ā€‰=ā€‰0.55). Additionally, there were significant differences between injury severity groups for mean diffusivity and fractional anisotropy at regions associated with the corticospinal tract (Pā€‰=ā€‰0.05).

CONCLUSION: These results indicate that DTI is sensitive to changes in brain tissue as a consequence of thoracic SCI.

Author List

Jirjis MB, Vedantam A, Budde MD, Kalinosky B, Kurpad SN, Schmit BD


Matthew Budde PhD Associate Professor in the Neurosurgery department at Medical College of Wisconsin
Shekar N. Kurpad MD, PhD Chair, Professor in the Neurosurgery department at Medical College of Wisconsin
Brian Schmit PhD Professor in the Biomedical Engineering department at Marquette University

MESH terms used to index this publication - Major topics in bold

Brain Diseases
Diffusion Tensor Imaging
Image Interpretation, Computer-Assisted
Reproducibility of Results
Sensitivity and Specificity
Spinal Cord Injuries
Trauma Severity Indices
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a