Faculty Collaboration Database

Plasma levels of nortriptyline and 10-hydroxynortriptyline and treatment-related electrocardiographic changes in the elderly depressed. J Psychiatr Res 1989;23(1):73-9

Date

01/01/1989

Pubmed ID

2754630

DOI

10.1016/0022-3956(89)90019-8

Scopus ID

2-s2.0-0024339393 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

Thirty-one elderly depressed patients were treated for seven weeks with nortriptyline with plasma levels kept between 50-180 ng/ml. Electrocardiograms were taken at the third and seventh weeks of treatment. There were significant increases in the PR interval, QTc interval, and heart rate from before and after treatment. However, there were no consistent correlations between electrocardiographic changes during treatment and plasma levels of nortriptyline, 10-hydroxynortriptyline and either of its two isomers (E-10-hydroxynortriptyline, Z-10-hydroxynortriptyline). Increased QRS duration after seven weeks of treatment was correlated with daily dose of nortriptyline.

Author List

McCue RE, Georgotas A, Nagachandran N, Abdul Basir M, Go EA, Suckow RF, Cooper TB

Author

Mir Abdul Basir MD Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged
Ambulatory Care
Depressive Disorder
Electrocardiography
Female
Heart
Humans
Isomerism
Male
Middle Aged
Nortriptyline