Faculty Collaboration Database

ASSESSING PHOTORECEPTOR STRUCTURE ASSOCIATED WITH ELLIPSOID ZONE DISRUPTIONS VISUALIZED WITH OPTICAL COHERENCE TOMOGRAPHY. Retina 2016 Jan;36(1):91-103

Date

07/15/2015

Pubmed ID

26166796

Pubmed Central ID

PMC4843118

DOI

10.1097/IAE.0000000000000618

Scopus ID

2-s2.0-84952932870 (requires institutional sign-in at Scopus site)   67 Citations

Abstract

PURPOSE: To compare images of photoreceptor layer disruptions obtained with optical coherence tomography (OCT) and adaptive optics scanning light ophthalmoscopy (AOSLO) in a variety of pathologic states.

METHODS: Five subjects with photoreceptor ellipsoid zone disruption as per OCT and clinical diagnoses of closed-globe blunt ocular trauma (n = 2), macular telangiectasia type 2 (n = 1), blue-cone monochromacy (n = 1), or cone-rod dystrophy (n = 1) were included. Images were acquired within and around photoreceptor lesions using spectral domain OCT, confocal AOSLO, and split-detector AOSLO.

RESULTS: There were substantial differences in the extent and appearance of the photoreceptor mosaic as revealed by confocal AOSLO, split-detector AOSLO, and spectral domain OCT en face view of the ellipsoid zone.

CONCLUSION: Clinically available spectral domain OCT, viewed en face or as B-scan, may lead to misinterpretation of photoreceptor anatomy in a variety of diseases and injuries. This was demonstrated using split-detector AOSLO to reveal substantial populations of photoreceptors in areas of no, low, or ambiguous ellipsoid zone reflectivity with en face OCT and confocal AOSLO. Although it is unclear if these photoreceptors are functional, their presence offers hope for therapeutic strategies aimed at preserving or restoring photoreceptor function.

Author List

Scoles D, Flatter JA, Cooper RF, Langlo CS, Robison S, Neitz M, Weinberg DV, Pennesi ME, Han DP, Dubra A, Carroll J

Author

Robert F. Cooper Ph.D Assistant Professor in the Biomedical Engineering department at Marquette University

MESH terms used to index this publication - Major topics in bold

Adult
Color Vision Defects
Eye Injuries
Female
Humans
Male
Middle Aged
Ophthalmoscopy
Photoreceptor Cells, Vertebrate
Retina
Retinal Telangiectasis
Retinitis Pigmentosa
Scotoma
Tomography, Optical Coherence
Visual Acuity
Wounds, Nonpenetrating
Young Adult