Effects of progesterone on experimental spinal cord injury. Brain Res 2007 Mar 16;1137(1):146-52
Date
01/06/2007Pubmed ID
17204255DOI
10.1016/j.brainres.2006.12.024Scopus ID
2-s2.0-33846906034 (requires institutional sign-in at Scopus site) 44 CitationsAbstract
Progesterone has been proposed to be protective to the central nervous system following injury. This study assessed progesterone supplementation in the setting of contusional spinal cord injury in male and female rats. Short-term (5 days of either 4 or 8 mg/kg progesterone) and long-term (14 days of either 8 or 16 mg/kg progesterone) therapy failed to show any significant alteration in locomotor functioning and injury morphometrics after 21 days. This study does not support progesterone as a potential therapeutic agent in spinal cord injury.
Author List
Fee DB, Swartz KR, Joy KM, Roberts KN, Scheff NN, Scheff SWAuthors
Dominic B. Fee MD Vice Chair, Professor in the Neurology department at Medical College of WisconsinKarin R. Swartz MD Assistant Dean, Professor in the Neurosurgery department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Analysis of VarianceAnimals
Disease Models, Animal
Female
Male
Motor Activity
Progesterone
Progestins
Rats
Rats, Sprague-Dawley
Recovery of Function
Sex Factors
Spinal Cord Injuries
Time Factors
