Faculty Collaboration Database

Noninvasive evaluation of electrical stimulation impacts on muscle hemodynamics via integrating diffuse optical spectroscopies with muscle stimulator. J Biomed Opt 2013 Oct;18(10):105002

Date

10/08/2013

Pubmed ID

24096298

Pubmed Central ID

PMC3790391

DOI

10.1117/1.JBO.18.10.105002

Scopus ID

2-s2.0-84886802522 (requires institutional sign-in at Scopus site)   12 Citations

Abstract

Technologies currently available for the monitoring of electrical stimulation (ES) in promoting blood circulation and tissue oxygenation are limited. This study integrated a muscle stimulator with a diffuse correlation spectroscopy (DCS) flow-oximeter to noninvasively quantify muscle blood flow and oxygenation responses during ES. Ten healthy subjects were tested using the integrated system. The muscle stimulator delivered biphasic electrical current to right leg quadriceps muscle, and a custom-made DCS flow-oximeter was used for simultaneous measurements of muscle blood flow and oxygenation in both legs. To minimize motion artifact of muscle fibers during ES, a novel gating algorithm was developed for data acquisition at the time when the muscle was relaxed. ES at 2, 10, and 50 Hz were applied for 20 min on each subject in three days sequentially. Results demonstrate that the 20-min ES at all frequencies promoted muscle blood flow significantly. However, only the ES at 10 Hz resulted in significant and persistent increases in oxy-hemoglobin concentration during and post ES. This pilot study supports the application of the integrated system to quantify tissue hemodynamic improvements for the optimization of ES treatment in patients suffering from diseases caused by poor blood circulation and low tissue oxygenation (e.g., pressure ulcer).

Author List

Shang Y, Lin Y, Henry BA, Cheng R, Huang C, Chen L, Shelton BJ, Swartz KR, Salles SS, Yu G

Author

Karin R. Swartz MD Assistant Dean, Professor in the Neurosurgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Algorithms
Artifacts
Blood Pressure
Electric Stimulation
Female
Heart Rate
Hemodynamics
Humans
Linear Models
Male
Muscle, Skeletal
Oximetry
Signal Processing, Computer-Assisted
Spectrum Analysis