Case report: profound hypotension after anesthetic induction with propofol in patients treated with rifampin. Anesth Analg 2013 Jul;117(1):61-4
Date
05/21/2013Pubmed ID
23687230DOI
10.1213/ANE.0b013e318292cbd0Scopus ID
2-s2.0-84880569978 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
Rifampin is commonly used for the treatment of tuberculosis and staphylococcal infections, as well as for prevention of infection in cardiac valve and bone surgeries. We report a case of profound hypotension after anesthesia induction with propofol in a patient who was treated with two 600 mg doses of rifampin for prophylaxis of infection before surgery. In a retrospective case-control study of 75 patients, we confirmed this potentially serious drug-drug interaction. After rifampin, there was a significant and prolonged arterial blood pressure reduction when patients received propofol, but not thiopental.
Author List
Mirzakhani H, Nozari A, Ehrenfeld JM, Peterfreund R, Szabo M, Walsh JL, Jiang Y, Sandberg W, Rosow C, Wang JAuthor
Jesse Ehrenfeld MD, MPH Sr Associate Dean, Director, Professor in the Advancing a Healthier Wisconsin Endowment department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAged
Anesthesia, Intravenous
Antibiotics, Antitubercular
Case-Control Studies
Drug Interactions
Female
Humans
Hypotension
Male
Middle Aged
Propofol
Retrospective Studies
Rifampin
Treatment Outcome