Faculty Collaboration Database

Effects of selected repeated intravitreal chemotherapeutic agents. Int Ophthalmol 1985 Nov;8(4):193-8

Date

11/01/1985

Pubmed ID

4086169

DOI

10.1007/BF00137646

Scopus ID

2-s2.0-0022370946 (requires institutional sign-in at Scopus site)   8 Citations

Abstract

The toxic effects of repeated intravitreal injections of selected chemotherapeutic agents were studied in female albino rabbits. Three groups of eyes participated in each therapeutic regimen. Agents studied were doxorubicin (dox), 3 and 5 micrograms; 5-fluorouracil (5-FU), 0.375 and 1.0 mg; bleomycin (bleo), 15 micrograms; thiotepa (thio), 12 micrograms; etoposide (VP-16), 150 micrograms; and methotrexate (MTX), 600 mic. Toxicity was evaluated using electroretinography (ERG) in 66% and histopathology in 100% of eyes 5 weeks following the initial injection and at least 2 weeks after the final injection of each series. Eyes receiving 2 doses of dox 3 micrograms showed no toxicity. Eyes receiving 3 or more doses of dox 3 micrograms and those treated with 2 or more doses of dox 5 demonstrated toxicity proportional to the number of doses received. Eyes treated with 5-FU 0.375 or 1.0 mg showed no toxic reaction. Successive intravitreal injections of 5-FU, 0.375 mg and dox 5 micrograms, and 5-FU, dox, and bleo produced no toxicity. Eyes treated with successive intravitreal injections of 5-FU, dox, bleo, and thio displayed decreased ERG response. The addition of VP-16 and MTX resulted in further loss of ERG response and more severe histologic retinal changes.

Author List

Vernot J, Peyman GA, Gailitis R, Fiscella R, Woodhouse M, Weinberg D

Author

David V. Weinberg MD Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Antimetabolites
Antineoplastic Agents
Cataract
Drug Combinations
Electroretinography
Eye
Female
Injections
Rabbits
Retina
Vitreous Body