Pathologic sequelae of allosensitization in liver transplantation. J Surg Res 2016 Jan;200(1):195-9
Date
08/09/2015Pubmed ID
26253457DOI
10.1016/j.jss.2015.06.047Scopus ID
2-s2.0-84938630209 (requires institutional sign-in at Scopus site) 1 CitationAbstract
The long-term impact of allosensitization between ABO compatible donor/recipient pairs in liver transplantation is unclear. Accumulating clinical evidence suggests that donor-specific antibody formation may lead to antibody-mediated rejection and is causally linked to pathologic injury, graft loss, and death. Although this immune-mediated graft dysfunction is increasingly being associated with poor outcomes, the specific pathologic sequelae are not defined. Herein, we examine the relationship between allosensitization, antibody-mediated rejection, and subsequent graft pathology.
Author List
Zimmerman MA, Schiller J, Kim J, Martin A, Selim M, Nydam TL, Cronin D 2nd, Hong JCMESH terms used to index this publication - Major topics in bold
ABO Blood-Group SystemGraft Rejection
Humans
Isoantibodies
Liver
Liver Transplantation
