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Pathologic sequelae of allosensitization in liver transplantation. J Surg Res 2016 Jan;200(1):195-9

Date

08/09/2015

Pubmed ID

26253457

DOI

10.1016/j.jss.2015.06.047

Scopus ID

2-s2.0-84938630209   1 Citation

Abstract

The long-term impact of allosensitization between ABO compatible donor/recipient pairs in liver transplantation is unclear. Accumulating clinical evidence suggests that donor-specific antibody formation may lead to antibody-mediated rejection and is causally linked to pathologic injury, graft loss, and death. Although this immune-mediated graft dysfunction is increasingly being associated with poor outcomes, the specific pathologic sequelae are not defined. Herein, we examine the relationship between allosensitization, antibody-mediated rejection, and subsequent graft pathology.

Author List

Zimmerman MA, Schiller J, Kim J, Martin A, Selim M, Nydam TL, Cronin D 2nd, Hong JC

Authors

Joohyun Kim MD, PhD Associate Professor in the Surgery department at Medical College of Wisconsin
Motaz Selim MBBS, MSc, MD, PhD Assistant Professor in the Surgery department at Medical College of Wisconsin
Michael A. Zimmerman MD, FACS Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

ABO Blood-Group System
Graft Rejection
Humans
Isoantibodies
Liver
Liver Transplantation
jenkins-FCD Prod-486 e3098984f26de787f5ecab75090d0a28e7f4f7c0