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Origin of CD11b+ macrophage-like cells in the CNS of PLP-overexpressing mice: low influx of haematogenous macrophages and unchanged blood-brain-barrier in the optic nerve. Mol Cell Neurosci 2008 Aug;38(4):489-94

Date

06/17/2008

Pubmed ID

18555697

DOI

10.1016/j.mcn.2008.04.009

Scopus ID

2-s2.0-47749106032   12 Citations

Abstract

We have recently reported that overexpression of proteolipid protein in oligodendrocytes leads to a pathologically relevant increase of both CD8+ T-lymphocytes and CD11b+ cells in the CNS. We now focussed on the origin of the CD11b+ cells in the optic nerve, a well established structure for the analysis of the mutant, using bone marrow chimeric mice. Although there is an age-related increase in CD11b+ cells in the myelinated part of the optic nerve of the mutants, the percentage of infiltrating cells was not increased, but enhanced proliferation was detectable. In the non-myelinated optic nerve head, the rate of infiltrating CD11b+ cells and albumin extravasation was high in both genotypes. However, albumin extravasation was also high in the rostral myelinated part, where CD11b+ cell influx was low. Our study demonstrates an intrinsic origin of CD11b+ cells in the presence of an unchanged blood-brain-barrier in a CNS myelin mutant.

Author List

Ip CW, Kohl B, Kleinschnitz C, Reuss B, Nave KA, Kroner A, Martini R

Author

Antje Kroner-Milsch MD, PhD Assistant Professor in the Neurosurgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Blood-Brain Barrier
Bone Marrow Transplantation
CD11b Antigen
Cell Differentiation
Hematopoietic Stem Cells
Macrophages
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Myelin Proteolipid Protein
Optic Nerve