Analysis of the monocyte chemoattractant protein 1 -2518 promoter polymorphism in patients with multiple sclerosis. Tissue Antigens 2004 Jul;64(1):70-3
Date
06/12/2004Pubmed ID
15191525DOI
10.1111/j.1399-0039.2004.00240.xScopus ID
2-s2.0-3042701415 (requires institutional sign-in at Scopus site) 12 CitationsAbstract
Cytokines and chemokines like the proinflammatory chemokine, monocytechemoattractant protein 1 (MCP-1) are important for the recruitment of inflammatory cells into multiple sclerosis (MS) lesions. Recently, a nucleotide substitution from adenosine to guanosine (A-->G) at position -2518 of the MCP-1 promoter was shown to be associated with increased MCP-1 expression. We analysed MCP-1 genotypes in 634 MS patients and 405 healthy controls. The allelic frequencies were comparable between both groups. No correlation was found between genotype and disease course, disease severity or age of disease onset. Although statistically no+ significant mRNA expression and MCP-1 secretion were elevated in patients carrying the mutant allele. Thus, our data could not reveal any association between the MCP-1 -2518 polymorphism and susceptibility to or clinical disease course of MS.
Author List
Kroner A, Mäurer M, Loserth S, Kleinschnitz C, Hemmer B, Rosche B, Toyka KV, Rieckmann PAuthor
Antje Kroner-Milsch MD, PhD Associate Professor in the Neurosurgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Alleles
Case-Control Studies
Chemokine CCL2
Female
Gene Expression
Gene Frequency
Humans
Male
Middle Aged
Multiple Sclerosis
Polymorphism, Genetic
Promoter Regions, Genetic
RNA, Messenger
