CCR4+T cell recruitment to the skin in mycosis fungoides: potential contributions by thymic stromal lymphopoietin and interleukin-16. Leuk Lymphoma 2015 Feb;56(2):440-9
Date
05/06/2014Pubmed ID
24794807DOI
10.3109/10428194.2014.919634Scopus ID
2-s2.0-84923854064 (requires institutional sign-in at Scopus site) 18 CitationsAbstract
Mycosis fungoides (MF) is characterized by skin accumulation of CCR4+CCR7- effector memory T cells; however the mechanism for their recruitment is not clearly identified. Thymic Stromal Lymphopoietin (TSLP) is a keratinocyte-derived cytokine that triggers Th2 immunity and is associated with T cell recruitment to the skin in atopic dermatitis. Interleukin-16 (IL-16) is a chemoattractant and growth factor for CD4+T cells. We hypothesized that TSLP and IL-16 could contribute to recruitment of malignant T cells in MF. We found elevated TSLP and IL-16 in very early stage patients' plasma and skin biopsies, prior to elevation in CCL22. Both TSLP and IL-16 induced migratory responses of CCR4+TSLPR+CD4+CCR7-CD31+cells, characteristic of malignant T cells in the skin. Co-stimulation also resulted in significant proliferative responses. We conclude that TSLP and IL-16, expressed at early stages of disease, function to recruit malignant T cells to the skin and contribute to their enhanced proliferation.
Author List
Tuzova M, Richmond J, Wolpowitz D, Curiel-Lewandrowski C, Chaney K, Kupper T, Cruikshank WAuthor
Keri S. Chaney MD Assistant Professor in the Dermatology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultCD4-Positive T-Lymphocytes
Cell Movement
Cell Proliferation
Cells, Cultured
Chemokine CCL22
Cytokines
Female
Flow Cytometry
Humans
Interleukin-16
Male
Microscopy, Fluorescence
Middle Aged
Mycosis Fungoides
Platelet Endothelial Cell Adhesion Molecule-1
Receptors, CCR4
Receptors, Cytokine
Skin
Skin Neoplasms
T-Lymphocytes
