Faculty Collaboration Database

Pressure and flow changes during Valsalva-like maneuvers in dogs following volume infusion. Am J Physiol 1977 Jul;233(1):H93-9

Date

07/01/1977

Pubmed ID

879339

DOI

10.1152/ajpheart.1977.233.1.H93

Scopus ID

2-s2.0-0017737644 (requires institutional sign-in at Scopus site)   10 Citations

Abstract

In eight dogs anesthetized with chloralose and urethan, Valsalva-like maneuvers (VLMs) were performed and central blood volume (CBV) measured following incremental volume loading with blood-dextran. Changes in blood pressure during VLM were characterized by 1) maximum change in systolic pressure (deltaPmax) during VLM; 2) change in systolic pressure during the first five beats of VLM (deltaP1-5); and 3) the change in pulse pressure during the first 10 beats of VLM. In three dogs, we also measured changes in right and left atrial pressure (PRA, PLA), esophageal pressure (PE), and pulmonary and aortic blood flow. We found that volume loading produced a continuous spectrum of hemodynamic changes culminating in the "square-wave" response. deltaPmax and deltaP1-5 correlated with changes in CBV. Changes in hemodynamic responses were produced by increases in CBV, and by incomplete prevention of systemic venous return during VLM. The mechanism of the square-wave response may be a combination of both these effects, with the latter the more significant of the two.

Author List

Wilkinson PL, Stowe DF, Tyberg JV, Parmley WW

Author

David F. Stowe MD, PhD Professor in the Anesthesiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Aorta
Blood Pressure
Blood Volume
Cardiovascular Physiological Phenomena
Dogs
Female
Heart Atria
Male
Pulmonary Circulation
Valsalva Maneuver