Faculty Collaboration Database

Can omphalocele ratio predict postnatal outcomes? J Pediatr Surg 2016 Jan;51(1):62-6

Date

11/07/2015

Pubmed ID

26541312

DOI

10.1016/j.jpedsurg.2015.10.010

Scopus ID

2-s2.0-84952938992 (requires institutional sign-in at Scopus site)   15 Citations

Abstract

BACKGROUND: The clinical course of patients with omphalocele is challenging to predict. There is no standard method to characterize omphalocele size. Previous studies suggest that the ratio of abdominal circumference to omphalocele defect in-utero is indicative of postnatal outcomes. We hypothesize that omphalocele ratio correlates with outcomes of primary closure versus staged closure.

METHODS: A retrospective chart review of all neonates diagnosed with omphalocele from 2002 to 2013 with prenatal ultrasounds available (n=30) was conducted. Omphalocele ratio was defined as omphalocele diameter/abdominal circumference (OD/AC). Data collected included primary versus staged closure, time to full feeds, duration of mechanical ventilation, and length of stay (LOS). Long-term outcomes and quality of life were also reported.

RESULTS: ROC curve analysis generated optimal OD/AC ratio of 0.26. Twenty of 30 patients had a ratio less than this cutoff. Sixty percent (12/20) in the low-ratio group achieved primary closure versus zero (0/10) in the high-ratio group (p=0.001). Time on mechanical ventilation was 15.8 days (low-ratio) versus 79 days (high-ratio) (p=0.05). LOS was 33.8 days (low-ratio) versus 85.6 days (high-ratio) (p=0.119). PedsQL™ mean score was 85.5 ± 11.0 (n=20) at long-term follow-up. Readmission rates yielded no difference.

CONCLUSIONS: The omphalocele ratio is a promising predictor of postnatal outcomes.

Author List

Fawley JA, Peterson EL, Christensen MA, Rein L, Wagner AJ

Authors

Erika Peterson MD Professor in the Obstetrics and Gynecology department at Medical College of Wisconsin
Lisa E. Rein Biostatistician III in the Institute for Health and Equity department at Medical College of Wisconsin
Amy Wagner MD Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Combined Modality Therapy
Decision Support Techniques
Female
Hernia, Umbilical
Herniorrhaphy
Humans
Infant, Newborn
Length of Stay
Male
Pregnancy
Prognosis
Quality of Life
ROC Curve
Respiration, Artificial
Retrospective Studies
Treatment Outcome
Ultrasonography, Prenatal