Developmental origins of cardiovascular risk in Jamaican children: the Vulnerable Windows Cohort study. Br J Nutr 2010 Oct;104(7):1026-33
Date
06/15/2010Pubmed ID
20540819DOI
10.1017/S0007114510001790Scopus ID
2-s2.0-77957912348 (requires institutional sign-in at Scopus site) 25 CitationsAbstract
Both intra-uterine and early childhood development contribute to the risk of developing CVD in adult life. We therefore evaluated the maternal, placental, fetal, birth, infant and childhood determinants of cardiovascular risk in a cohort of Afro-Jamaican children. The Vulnerable Windows Cohort is a longitudinal survey of 569 mothers and their offspring recruited from the first trimester. The offspring's anthropometry was measured at birth, at 6 weeks, every 3 months to 1 year and then every 6 months. At mean age 11.5 years, fasting blood was sampled for glucose, insulin and lipids. Analyses were confined to 296 women and their offspring who had complete data. Waist circumference (WC) was related to maternal weight and BMI, placental weight and to the size of the offspring in utero, at birth and the rate of growth in childhood (P < 0.05). Total cholesterol, TAG and glucose concentrations were unrelated to maternal, placental, fetal, neonatal and childhood measurements. Fasting insulin and homeostasis model assessment of insulin resistance were related to maternal weight and BMI (P < 0.05), but not after adjusting for WC. HDL-cholesterol was inversely related to placental and birth weight, and inversely related to weight and BMI throughout childhood (P < 0.001), but not after adjusting for WC. Systolic blood pressure was directly related to maternal weight, child's height, weight and BMI (P < 0.05), but not after adjustment for WC. Systolic blood pressure and fasting glucose concentration were inversely related to birth weight in boys but directly associated in girls. We concluded that maternal anthropometry during pregnancy, fetal size, and childhood growth rate contribute to cardiovascular risk factors in childhood.
Author List
Boyne MS, Osmond C, Fraser RA, Reid M, Taylor-Bryan C, Soares-Wynter S, Forrester TEAuthor
Raphael Fraser PhD Assistant Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAfrica
Birth Weight
Blood Glucose
Blood Pressure
Body Mass Index
Body Weight
Cardiovascular Diseases
Child
Cholesterol, HDL
Female
Fetal Development
Growth
Humans
Infant, Newborn
Insulin
Insulin Resistance
Jamaica
Male
Organ Size
Placenta
Pregnancy
Risk Factors
Sex Factors
Waist Circumference
Young Adult
