Growth, body composition, and the onset of puberty: longitudinal observations in Afro-Caribbean children. J Clin Endocrinol Metab 2010 Jul;95(7):3194-200
Date
04/30/2010Pubmed ID
20427487DOI
10.1210/jc.2010-0080Scopus ID
2-s2.0-77954919345 (requires institutional sign-in at Scopus site) 64 CitationsAbstract
CONTEXT: Childhood growth and body composition may influence the onset of puberty.
OBJECTIVE: We examined the effects of birth size, growth rates throughout childhood, and body composition on the onset of puberty in Afro-Caribbean children.
DESIGN AND SETTING: This was a longitudinal birth cohort study (the Vulnerable Windows Cohort Study) in Jamaica.
SUBJECTS AND MEASUREMENTS: The anthropometry (weight, height, skinfold measurements, and waist circumference) of 259 children was measured at birth, at 6 wk, every 3 months to 2 yr, and then every 6 months. Tanner staging for puberty and orchidometry were performed every 6 months starting at approximately age 8 yr. Bioelectrical impedance was done at age 11 yr.
RESULTS: In the girls, thelarche, pubarche, and menarche occurred at median ages of 8.8, 9.9, and 12.0 yr, respectively. Pubarche in boys occurred at a median age of 11.3 yr when the median testicular volume was 2.8 ml. Faster weight gain during infancy (age 0-6 months) and childhood, but not birth size, was associated with more advanced puberty (P values <0.05). Fat mass at age 8 yr was associated with more advanced puberty (P values <0.001) in both sexes. At age 11 yr, lean mass, but not fat mass, was associated with more advanced puberty (P values <0.001).
CONCLUSION: These data support the hypothesis that faster growth throughout childhood, especially with fat mass accretion, is associated with more advanced puberty apart from menarche. With the onset of puberty, lean mass accretion significantly increases.
Author List
Boyne MS, Thame M, Osmond C, Fraser RA, Gabay L, Reid M, Forrester TEAuthor
Raphael Fraser PhD Assistant Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAnthropometry
Birth Weight
Body Composition
Body Mass Index
Child
Child Development
Child, Preschool
Electric Impedance
Female
Humans
Infant
Infant, Newborn
Jamaica
Longitudinal Studies
Male
Puberty
Regression Analysis
Sex Factors
Weight Gain
