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Pure Erythroid Leukemia Mimicking Ewing Sarcoma/Primitive Neuroectodermal Tumor in an Infant. Pediatr Blood Cancer 2016 May;63(5):935-7

Date

01/17/2016

Pubmed ID

26773805

DOI

10.1002/pbc.25898

Scopus ID

2-s2.0-84980042088   4 Citations

Abstract

Pure erythroid leukemia (PEL) is a rare type of acute myeloid leukemia (AML) with a very aggressive clinical course. Presentation as a myeloid/erythroid sarcoma is exceedingly rare. We describe an infantile PEL presenting as a multifocal myeloid sarcoma, clinically and pathologically mimicking Ewing sarcoma/PNET family of tumors. The patient died 8 weeks after the initial presentation due to widespread disease. Our case shows that PEL needs to be considered in the differential diagnosis of small round blue cell tumors in infancy. A meticulous workup including immunohistochemistry, flow cytometry, molecular, and cytogenetic studies was required to reach the diagnosis.

Author List

Lapadat R, Tower RL 2nd, Tam W, Orazi A, Gheorghe G

Author

Richard L. Tower MD Associate Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Fatal Outcome
Humans
Infant
Leukemia, Erythroblastic, Acute
Male
Neuroectodermal Tumors, Primitive
Sarcoma, Ewing
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a