Pure Erythroid Leukemia Mimicking Ewing Sarcoma/Primitive Neuroectodermal Tumor in an Infant. Pediatr Blood Cancer 2016 May;63(5):935-7
Date
01/17/2016Pubmed ID
26773805DOI
10.1002/pbc.25898Scopus ID
2-s2.0-84980042088 (requires institutional sign-in at Scopus site) 9 CitationsAbstract
Pure erythroid leukemia (PEL) is a rare type of acute myeloid leukemia (AML) with a very aggressive clinical course. Presentation as a myeloid/erythroid sarcoma is exceedingly rare. We describe an infantile PEL presenting as a multifocal myeloid sarcoma, clinically and pathologically mimicking Ewing sarcoma/PNET family of tumors. The patient died 8 weeks after the initial presentation due to widespread disease. Our case shows that PEL needs to be considered in the differential diagnosis of small round blue cell tumors in infancy. A meticulous workup including immunohistochemistry, flow cytometry, molecular, and cytogenetic studies was required to reach the diagnosis.
Author List
Lapadat R, Tower RL 2nd, Tam W, Orazi A, Gheorghe GAuthor
Richard L. Tower MD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Fatal OutcomeHumans
Infant
Leukemia, Erythroblastic, Acute
Male
Neuroectodermal Tumors, Primitive
Sarcoma, Ewing
