Faculty Collaboration Database

Predictors of success for drug discontinuation following neonatal seizures. Pediatr Neurol 1988;4(1):13-7

Date

01/01/1988

Pubmed ID

3233103

DOI

10.1016/0887-8994(88)90018-5

Scopus ID

2-s2.0-0023856284 (requires institutional sign-in at Scopus site)   22 Citations

Abstract

Guidelines for the discontinuation of antiepileptic drugs in neonatal seizures are not well defined. Some studies suggested possible criteria for antiepileptic drug discontinuation but no precise criteria have emerged. We performed a retrospective analysis of 58 infants with neonatal seizures during a 3 year period. Antiepileptic drugs were discontinued when patients were seizure-free for 3 months, had normal electroencephalography initially or at subsequent examination, and had a nonfocal examination. Normal initial electroencephalography was demonstrated to be a reliable predictor for discontinuing antiepileptic drugs successfully in 18 of 22 term infants; normal subsequent electroencephalography was a reliable predictor of successful discontinuation of antiepileptic drugs in 9 of 10 premature infants.

Author List

Brod SA, Ment LR, Ehrenkranz RA, Bridgers S

MESH terms used to index this publication - Major topics in bold

Anticonvulsants
Brain
Electroencephalography
Humans
Infant, Newborn
Seizures