Predictors of success for drug discontinuation following neonatal seizures. Pediatr Neurol 1988 Jan-Feb;4(1):13-7
Date
01/01/1988Pubmed ID
3233103DOI
10.1016/0887-8994(88)90018-5Scopus ID
2-s2.0-0023856284 15 CitationsAbstract
Guidelines for the discontinuation of antiepileptic drugs in neonatal seizures are not well defined. Some studies suggested possible criteria for antiepileptic drug discontinuation but no precise criteria have emerged. We performed a retrospective analysis of 58 infants with neonatal seizures during a 3 year period. Antiepileptic drugs were discontinued when patients were seizure-free for 3 months, had normal electroencephalography initially or at subsequent examination, and had a nonfocal examination. Normal initial electroencephalography was demonstrated to be a reliable predictor for discontinuing antiepileptic drugs successfully in 18 of 22 term infants; normal subsequent electroencephalography was a reliable predictor of successful discontinuation of antiepileptic drugs in 9 of 10 premature infants.
Author List
Brod SA, Ment LR, Ehrenkranz RA, Bridgers SAuthor
Staley A. Brod MD Professor in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnticonvulsantsBrain
Electroencephalography
Humans
Infant, Newborn
Seizures
