Post-Treatment Controllers: Role in HIV "Cure" Research. Curr HIV/AIDS Rep 2016 Feb;13(1):1-9
Date
01/20/2016Pubmed ID
26781112DOI
10.1007/s11904-016-0296-xScopus ID
2-s2.0-84954566469 (requires institutional sign-in at Scopus site) 24 CitationsAbstract
Descriptions of individuals who are able to control viral replication in the absence of antiretroviral therapy after receiving short-term therapy early in infection ("post-treatment controllers") has generated excitement and controversy within the field. As with natural or "elite" controllers, these cases provide hope that a long-term remission or "functional cure" might one day be possible. Here, we review what is known and not known about these cases and discuss the immunologic factors that may allow these unique individuals to be maintain viral control and may be important for future curative strategies.
Author List
Cockerham LR, Hatano H, Deeks SGAuthor
Leslie Cockerham MD Associate Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Anti-Retroviral AgentsAntiretroviral Therapy, Highly Active
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Female
HIV Infections
HIV-1
Humans
Male
Viral Load
Virus Latency
Virus Replication
