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Langerhans cell histiocytosis of the digestive tract identified on an upper gastrointestinal examination. Pediatr Radiol 2016 Aug;46(9):1341-4

Date

02/18/2016

Pubmed ID

26886914

DOI

10.1007/s00247-016-3558-2

Scopus ID

2-s2.0-84958817648   2 Citations

Abstract

Langerhans cell histiocytosis (LCH) with involvement of the gastrointestinal tract is rare and typically identified in patients with systemic disease. We describe a 16-month-old girl who initially presented with bilious vomiting, failure to thrive and a rash. An upper gastrointestinal (GI) examination revealed loss of normal mucosal fold pattern and luminal narrowing within the duodenum, prompting endoscopic biopsy. Langerhans cell histiocytosis of the digestive tract was confirmed by histopathology. A skeletal survey and skin biopsy identified other systemic lesions. Although uncommon, it is important to consider LCH in the differential diagnosis for gastrointestinal symptoms of unclear origin, especially when seen with concurrent rash. Findings of gastrointestinal involvement on upper GI examination include loss of normal mucosal fold pattern and luminal narrowing in the few published case reports.

Author List

Zei M, Meyers AB, Boyd KP, Larson-Nath C, Suchi M

Author

Mariko Suchi MD, PhD Associate Professor in the Pathology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Biopsy
Diagnosis, Differential
Endoscopy, Gastrointestinal
Female
Gastrointestinal Diseases
Histiocytosis, Langerhans-Cell
Humans
Infant
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a