Heat shock proteins in the kidney. Pediatr Nephrol 2016 Oct;31(10):1561-70
Date
02/26/2016Pubmed ID
26913726DOI
10.1007/s00467-015-3297-xScopus ID
2-s2.0-84975757558 (requires institutional sign-in at Scopus site) 28 CitationsAbstract
Heat shock proteins (Hsps) are essential to cell survival through their function as protein chaperones. The role they play in kidney health and disease is varied. Hsp induction may be either beneficial or detrimental to the kidney, depending on the specific Hsp, type of cell, and context. This review addresses the role of Hsps in the kidney, including during development, as osmoprotectants, and in various kidney disease models. Heat shock transcription factor, activated by a stress on renal cells, induces Hsp elaboration and separately regulates immune responses that can contribute to renal injury. Induced Hsps in the intracellular compartment are mostly beneficial in the kidney by stabilizing and restoring cell architecture and function through acting as protein chaperones. Intracellular Hsps also inhibit apoptosis and facilitate cell proliferation, preserving renal tubule viability after acute injury, but enhancing progression of cystic kidney disease and malignancy. Induced Hsps in the extracellular compartment, either circulating or located on outer cell membranes, are mainly detrimental through enhancing inflammation pathways to injury. Correctly harnessing these stress proteins promises the opportunity to alter the course of acute and chronic kidney disease.
Author List
Sreedharan R, Van Why SKMESH terms used to index this publication - Major topics in bold
AnimalsHeat-Shock Proteins
Humans
Kidney
Kidney Diseases
