Serum antibodies associated with complex inflammatory bowel disease. Inflamm Bowel Dis 2013 Jun;19(7):1499-505
Date
05/25/2013Pubmed ID
23702714DOI
10.1097/MIB.0b013e318281f2a1Scopus ID
2-s2.0-84879080975 (requires institutional sign-in at Scopus site) 28 CitationsAbstract
BACKGROUND: Antibodies to microbial antigens have been associated with specific diagnoses and phenotypes of inflammatory bowel disease. We evaluated the prevalence of pANCA, IgA and IgG anti-Saccharomyces cerevisiae antibodies, anti-OmpC, and anti-flagellin in a large well-defined population of patients with Crohn's disease (CD) and ulcerative colitis (UC) and analyzed for various clinical outcomes.
METHODS: Samples were collected from 391 patients with CD, 207 patients with UC, and 62 healthy controls. Patients were phenotyped using the Montreal classification. Blinded serological analyses were performed for pANCA, IgA and IgG anti-Saccharomyces cerevisiae antibodies, anti-OmpC, and anti-flagellin.
RESULTS: In CD, increasing quantitative levels for antibodies were associated with a younger age of diagnosis, longer disease duration, increased surgeries, ileocolonic and perianal disease, and internal perforating behavior. In UC, they were associated with colectomy. An increasing number of seropositive antibodies in CD was associated with a younger age at diagnosis, increased disease duration, ileocolonic and perianal disease, internal penetrating and stricturing behavior, and increased surgeries. Multivariate analysis confirmed the association of antimicrobial antibodies with features of complicated CD and UC.
CONCLUSIONS: Increased serological markers are associated with a more aggressive CD phenotype and an increased need for colectomy in UC. This raises the possibility for use of these markers in patients at risk of complex disease.
Author List
Elkadri AA, Stempak JM, Walters TD, Lal S, Griffiths AM, Steinhart AH, Silverberg MSAuthor
Abdul Aziz Elkadri MD Associate Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Antibodies, Antineutrophil Cytoplasmic
Canada
Colitis, Ulcerative
Crohn Disease
Female
Flagellin
Follow-Up Studies
Humans
Immunoglobulin A
Immunoglobulin G
Male
Prevalence
Prognosis
Saccharomyces cerevisiae
Young Adult
