Genes and environment in neonatal intraventricular hemorrhage. Semin Perinatol 2015 Dec;39(8):592-603
Date
10/31/2015Pubmed ID
26516117Pubmed Central ID
PMC4668116DOI
10.1053/j.semperi.2015.09.006Scopus ID
2-s2.0-84946738462 (requires institutional sign-in at Scopus site) 40 CitationsAbstract
Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.
Author List
Ment LR, Ådén U, Bauer CR, Bada HS, Carlo WA, Kaiser JR, Lin A, Cotten CM, Murray J, Page G, Hallman M, Lifton RP, Zhang H, Gene Targets for IVH Study Group and the Neonatal Research NetworkAuthor
Girija Ganesh Konduri MD Chief, Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Apgar ScoreCerebral Ventricles
Female
Gene-Environment Interaction
Genetic Predisposition to Disease
Genetic Variation
Genome-Wide Association Study
Gestational Age
Humans
Infant
Infant, Newborn
Infant, Premature
Intracranial Hemorrhages
Pregnancy
Risk Factors
United States
