Sleep deprivation in the rat: VII. Immune function. Sleep 1989 Feb;12(1):47-52
Date
02/01/1989Pubmed ID
2784583DOI
10.1093/sleep/12.1.47Scopus ID
2-s2.0-0024496844 (requires institutional sign-in at Scopus site) 50 CitationsAbstract
Immune function studies were performed on splenic lymphocytes obtained from rats subjected to total or paradoxical sleep deprivation. Spleen cell counts, in vitro lymphocyte proliferation responses to mitogens, and in vitro and in vivo plaque-forming cell responses to antigens were obtained. Sleep-deprived rats were roughly equivalent to both their yoked controls and home-cage controls in all assays. The results do not support the hypothesis that sleep deprivation results in immune suppression as measured by the above-mentioned parameters.
Author List
Benca RM, Kushida CA, Everson CA, Kalski R, Bergmann BM, Rechtschaffen AAuthor
Carol A. Everson PhD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAntibody Formation
B-Lymphocytes
Cerebral Cortex
Electroencephalography
Immune Tolerance
Lymphocyte Activation
Male
Rats
Rats, Inbred Strains
Sleep Deprivation
Sleep Stages
Sleep, REM
T-Lymphocytes