Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

A prospective analysis of factors associated with decreased physical activity in patients with cirrhosis undergoing transplant evaluation. Clin Transplant 2015 Nov;29(11):958-64

Date

08/13/2015

Pubmed ID

26263921

Pubmed Central ID

PMC4624476

DOI

10.1111/ctr.12602

Scopus ID

2-s2.0-84945460081 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

BACKGROUND: Physical activity (PA) has been associated with improved recovery time after transplantation. Handgrip strength has been related to post-transplant outcomes.

AIM: To evaluate predictors of PA and grip strength in patients with cirrhosis undergoing liver transplant evaluation.

METHODS: Single-center, prospective analysis.

RESULTS: One hundred patients were evaluated (54% male, mean age 53 ± 9). Common etiologies of liver disease were non-alcoholic steatohepatitis (27%), hepatitis C (22%) and alcoholic liver disease (21%). Mean model of end-stage liver disease (MELD) score was 13.5. Forty-one percent had a history of smoking. Ninety-three patients completed the International Physical Activity Questionnaire (IPAQ). The median total PA score was 33 metabolic equivalent (MET)-min/wk. The mean total grip strength was 62.1 ± 22 lb. Total grip strength was found to be an independent predictor of low-moderate PA (OR 4.7, 95% CI 1.4-16.2, p = 0.038), and smoking was the only significant factor associated with reduced grip strength (OR 3.4, 95% CI 1.4-8, p = 0.005).

CONCLUSIONS: Patients with end-stage liver disease undergoing liver transplant evaluation have reduced total PA by IPAQ. Total grip strength was found to be a significant predictor of low-moderate PA in patients with cirrhosis. Smoking is a risk factor for reduced grip strength, an important indicator of muscle wasting in cirrhotics.

Author List

Dela Cruz AC, Vilchez V, Kim S, Barnes B, Ravinuthala A, Zanni A, Galuppo R, Sourianarayanane A, Patel T, Maynard E, Shah MB, Daily MF, Uhl T, Esser K, Gedaly R

Author

Achuthan Sourianarayanane MD Associate Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Aged
Case-Control Studies
End Stage Liver Disease
Female
Follow-Up Studies
Hand Strength
Humans
Liver Cirrhosis
Liver Transplantation
Male
Middle Aged
Motor Activity
Prognosis
Prospective Studies
Risk Factors
Severity of Illness Index