A prospective analysis of factors associated with decreased physical activity in patients with cirrhosis undergoing transplant evaluation. Clin Transplant 2015 Nov;29(11):958-64
Date
08/13/2015Pubmed ID
26263921Pubmed Central ID
PMC4624476DOI
10.1111/ctr.12602Scopus ID
2-s2.0-84945460081 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
BACKGROUND: Physical activity (PA) has been associated with improved recovery time after transplantation. Handgrip strength has been related to post-transplant outcomes.
AIM: To evaluate predictors of PA and grip strength in patients with cirrhosis undergoing liver transplant evaluation.
METHODS: Single-center, prospective analysis.
RESULTS: One hundred patients were evaluated (54% male, mean age 53 ± 9). Common etiologies of liver disease were non-alcoholic steatohepatitis (27%), hepatitis C (22%) and alcoholic liver disease (21%). Mean model of end-stage liver disease (MELD) score was 13.5. Forty-one percent had a history of smoking. Ninety-three patients completed the International Physical Activity Questionnaire (IPAQ). The median total PA score was 33 metabolic equivalent (MET)-min/wk. The mean total grip strength was 62.1 ± 22 lb. Total grip strength was found to be an independent predictor of low-moderate PA (OR 4.7, 95% CI 1.4-16.2, p = 0.038), and smoking was the only significant factor associated with reduced grip strength (OR 3.4, 95% CI 1.4-8, p = 0.005).
CONCLUSIONS: Patients with end-stage liver disease undergoing liver transplant evaluation have reduced total PA by IPAQ. Total grip strength was found to be a significant predictor of low-moderate PA in patients with cirrhosis. Smoking is a risk factor for reduced grip strength, an important indicator of muscle wasting in cirrhotics.
Author List
Dela Cruz AC, Vilchez V, Kim S, Barnes B, Ravinuthala A, Zanni A, Galuppo R, Sourianarayanane A, Patel T, Maynard E, Shah MB, Daily MF, Uhl T, Esser K, Gedaly RAuthor
Achuthan Sourianarayanane MD Associate Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAged
Case-Control Studies
End Stage Liver Disease
Female
Follow-Up Studies
Hand Strength
Humans
Liver Cirrhosis
Liver Transplantation
Male
Middle Aged
Motor Activity
Prognosis
Prospective Studies
Risk Factors
Severity of Illness Index