Faculty Collaboration Database

Risk factors of non-alcoholic fatty liver disease in patients with inflammatory bowel disease. J Crohns Colitis 2013 Sep;7(8):e279-85

Date

11/20/2012

Pubmed ID

23158500

DOI

10.1016/j.crohns.2012.10.015

Scopus ID

2-s2.0-84880036121 (requires institutional sign-in at Scopus site)   104 Citations

Abstract

BACKGROUND: Metabolic risk factors are associated with non-alcoholic fatty liver disease (NAFLD), but they are less frequent in inflammatory bowel disease (IBD).

AIM: This study evaluates the frequency of NAFLD and its risk factors among IBD patients including anti-TNF-α therapy.

METHODS: IBD patients who underwent abdominal imaging from January, 2009 to December, 2010 were analyzed in this nested, case-controlled study. IBD patients with NAFLD by imaging were compared with those who had no evidence of NAFLD (control).

RESULTS: Among 928 IBD patients, 76 (8.2%) had evidence of NAFLD by imaging, and were compared to 141 patients without NAFLD evaluated (study: control ratio=~1:2). NAFLD patients were older (46.0 ± 13.3 vs. 42.0 ±14.1 years; p=0.018) and had a later onset of IBD compared to the control group (37.2 ± 15.3 vs. 28.7 ± 23.8 years; p=0.002). Metabolic syndrome was present in 29.0% of NAFLD patients, with a median Adult Treatment Panel risk factor of 2 [Interquartile range 1,3]. Patients not receiving anti-TNF-α therapy had a higher occurrence of NAFLD (p=0.048). In multivariate analysis, hypertension (OR=3.5), obesity (OR=2.1), small bowel surgeries (OR=3.7), and use of steroids at the time of imaging (OR=3.7) were independent factors associated with NAFLD.

CONCLUSION: NAFLD occurred in 8.2% of the IBD population. NAFLD patients were older and had a later onset of IBD disease. IBD patients develop NAFLD with fewer metabolic risk factors than non-IBD NAFLD patients. It is also less common among patients who received anti-TNF-α therapy.

Author List

Sourianarayanane A, Garg G, Smith TH, Butt MI, McCullough AJ, Shen B

Author

Achuthan Sourianarayanane MD Associate Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Age Factors
Age of Onset
Case-Control Studies
Colitis, Ulcerative
Crohn Disease
Fatty Liver
Female
Humans
Hypertension
Intestine, Small
Male
Metabolic Syndrome
Middle Aged
Non-alcoholic Fatty Liver Disease
Obesity
Prevalence
Risk Factors
Steroids
Tumor Necrosis Factor-alpha