Faculty Collaboration Database

Atrial natriuretic factor attenuates carotid baroreflex-mediated cardioacceleration in humans. Am J Physiol 1988 Apr;254(4 Pt 2):R590-4

Date

04/11/1988

Pubmed ID

2965521

DOI

10.1152/ajpregu.1988.254.4.R590

Scopus ID

2-s2.0-0023942816 (requires institutional sign-in at Scopus site)   35 Citations

Abstract

We tested the hypothesis that infusions of atrial natriuretic factor (ANF) attenuate carotid baroreflex-mediated tachycardia in humans. The afferent profile from carotid baroreceptors was altered by repeated, intermittent random applications of neck suction (40 mmHg) and neck pressure (20 mmHg) to healthy volunteers during supine control and during infusions of 15 (n = 6) or 25 ng.kg-1.min-1 (n = 9) of alpha-human ANF or during placebo (n = 9). ANF infusions resulted in five- and eightfold increases of plasma ANF, which did not alter base-line cardiac interval, blood pressure, respiratory sinus arrhythmia, plasma renin activity, vasopressin, or norepinephrine but did reduce central venous pressure. Reflex bradycardic responses were unaltered during these infusions. Reflex tachycardic responses to carotid compression were significantly blunted (up to 40%) during infusions of ANF and were unchanged during placebo. These responses may be due to a sensitization of cardiac receptors and augmentation of cardiac-vagal afferent traffic by ANF, which diminishes reflex cardiac-sympathetic outflow during carotid baroreceptor unloading.

Author List

Ebert TJ, Cowley AW Jr

Authors

Allen W. Cowley Jr PhD Professor in the Physiology department at Medical College of Wisconsin
Thomas J. Ebert MD, PhD Adjunct Professor in the Anesthesiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aldosterone
Atrial Natriuretic Factor
Blood Pressure
Carotid Sinus
Female
Heart Rate
Humans
Male
Norepinephrine
Pressoreceptors
Reflex
Renin
Vasopressins