Widespread hyperplasia induced by transgenic TGFalpha in ApcMin mice is associated with only regional effects on tumorigenesis. Carcinogenesis 2008 Sep;29(9):1825-30
Date
03/04/2008Pubmed ID
18310091Pubmed Central ID
PMC2547353DOI
10.1093/carcin/bgn038Scopus ID
2-s2.0-51849136546 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
Using a mouse predisposed to neoplasia by a germ line mutation in Apc (Apc(Min)), we tested whether induced hyperplasia is sufficient to increase intestinal tumor multiplicity or size in the intestine. We found that hyperplasia in the jejunum correlated with a significant increase in tumor multiplicity. However, tumor multiplicity was unchanged in the hyperplastic colon. This result indicates that even an intestine predisposed to neoplasia can, in certain regions including the colon, accommodate net increased cell growth without developing more neoplasms. Where hyperplasia correlated with increased tumor multiplicity, it did not increase the size or net growth of established tumors. This result suggests that the event linking hyperplasia and neoplasia in the jejunum is tumor establishment. Two novel observations arose in our study: the multiple intestinal neoplasia (Min) mutation partially suppressed both mitosis and transforming growth factor alpha-induced hyperplasia throughout the intestine; and zinc treatment alone increased tumor multiplicity in the duodenum of Min mice.
Author List
Bilger A, Sullivan R, Prunuske AJ, Clipson L, Drinkwater NR, Dove WFAuthor
Amy Jeanette Prunuske PhD Associate Professor in the Medical School Regional Campuses department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsApoptosis
Colonic Neoplasms
Duodenal Neoplasms
Ethylnitrosourea
Female
Genes, APC
Hyperplasia
Ileal Neoplasms
Jejunal Neoplasms
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Mitosis
Mutation
Transforming Growth Factor alpha
Transgenes
Zinc
