Faculty Collaboration Database

Impact of intravenous magnesium infusion rate during ambulatory replacements on serum magnesium concentrations after allogeneic stem cell transplant. Support Care Cancer 2016 Oct;24(10):4237-40

Date

05/04/2016

Pubmed ID

27137211

DOI

10.1007/s00520-016-3252-9

Scopus ID

2-s2.0-84965056679 (requires institutional sign-in at Scopus site)   5 Citations

Abstract

PURPOSE: For an outpatient cancer center to operate efficiently, optimizing the use of chair time is essential. Allogeneic hematopoietic cell transplant (allo-HCT) recipients are seen frequently in this setting after hospital discharge and regularly for several months thereafter. Aggressive electrolyte replacement is commonly required in these patients, primarily due to renal wasting with calcineurin inhibitor use. Frequent intravenous (IV) magnesium repletion, requiring several hours of infusion time, is often needed in these patients to adequately manage their magnesium deficiencies. The purpose of this study is to explore the impact of extending the infusion rate of intravenous magnesium sulfate on the frequency and degree of IV magnesium replacements required in allo-HCT recipients.

METHODS: We conducted a retrospective study to compare two cohorts of patients administered IV magnesium sulfate at a rate of 4 g/1 h versus 4 g/2 h.

RESULTS: A total of 103 continuous patients were assessed in two groups as cohort 1 at the 4 g/1 h rate and cohort 2 at the 4 g/2 h rate. Cohort 1 required less IV magnesium per outpatient visit (median 2.2 vs. 2.9 g/visit, P = 0.0211) and less total IV magnesium replacement through day +100 (median 68 vs. 85 g, P = 0.0479) than cohort 2.

CONCLUSION: These data suggest that there is no apparent benefit of prolonging magnesium infusion from 1 to 2 h in our outpatient allo-HCT population.

Author List

Snyder M, Shillingburg A, Newton M, Hamadani M, Kanate AS, Craig M, Cumpston A

Author

Mehdi H. Hamadani MD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Cohort Studies
Female
Hematopoietic Stem Cell Transplantation
Humans
Infusions, Intravenous
Magnesium
Male
Middle Aged
Retrospective Studies
Transplantation Conditioning
Transplantation, Homologous
Young Adult