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Vasopressin in cardiovascular patients: therapeutic implications. Expert Opin Pharmacother 2002 May;3(5):505-12

Date

05/09/2002

Pubmed ID

11996629

DOI

10.1517/14656566.3.5.505

Scopus ID

2-s2.0-0036094077   8 Citations

Abstract

Vasopressin is a vital homeostatic protein which regulates fluid balance via its antidiuretic effects and vascular tone via its vasoconstrictive effects. Endogenous vasopressin deficiency has been implicated in several disease states resulting in vasodilatory shock. In particular, vasopressin levels are low in patients following cardiac surgery and in those with ventricular dysrhythmias. Several recent studies have demonstrated the effectiveness of exogenous vasopressin in providing haemodynamic support in patients with postcardiopulmonary bypass vasodilatory shock and refractory ventricular fibrillation. This manuscript reviews the pathophysiological and clinical basis for vasopressin replacement in patients with cardiovascular collapse.

Author List

Zimmerman MA, Albright TN, Raeburn CD, Selzman CH

Author

Michael A. Zimmerman MD, FACS Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Cardiopulmonary Resuscitation
Cardiovascular Diseases
Deamino Arginine Vasopressin
Hemostatics
Humans
Postoperative Period
Vasopressins
jenkins-FCD Prod-486 e3098984f26de787f5ecab75090d0a28e7f4f7c0