Faculty Collaboration Database

The case for beta-adrenergic blockade as prophylaxis against perioperative cardiovascular morbidity and mortality. Arch Surg 2001 Mar;136(3):286-90

Date

03/20/2001

Pubmed ID

11231847

DOI

10.1001/archsurg.136.3.286

Scopus ID

2-s2.0-0035089638 (requires institutional sign-in at Scopus site)   36 Citations

Abstract

Perioperative morbidity and mortality are frequently cardiac in origin. Many studies have prospectively attempted to define risk factors for cardiac ischemic events. Although we can now identify high-risk patients, optimal cardioprotective management strategies remain unclear. Treatment with beta-adrenergic antagonists decreases myocardial oxygen consumption and is generally well tolerated. This article reviews the physiologic and clinical basis for using these agents as prophylaxis against cardiovascular events in high-risk surgical patients.

Author List

Selzman CH, Miller SA, Zimmerman MA, Harken AH

MESH terms used to index this publication - Major topics in bold

Adrenergic beta-Antagonists
Animals
Arrhythmias, Cardiac
Heart Failure
Humans
Myocardial Infarction
Myocardium
Oxygen Consumption
Postoperative Complications
Premedication
Randomized Controlled Trials as Topic
Survival Rate