Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Dystrophin expression improves myofiber survival in mdx muscle following intramuscular plasmid DNA injection. Hum Mol Genet 1993 Dec;2(12):2055-61

Date

12/01/1993

Pubmed ID

8111373

DOI

10.1093/hmg/2.12.2055

Abstract

Expression of Becker-like and full-length human dystrophins was stable for at least 6 months in mdx mouse muscle following intramuscular plasmid DNA injection. Intramuscular injection of a single plasmid DNA encoding both luciferase and dystrophin resulted in stable luciferase expression for at least 2 months in mdx muscle, whereas injection of plasmid DNA encoding only luciferase did not result in stable luciferase expression. These results suggest that expression of either full-length or Becker-like dystrophins protects mdx mouse myofibers from degeneration.

Author List

Danko I, Fritz JD, Latendresse JS, Herweijer H, Schultz E, Wolff JA

Author

Jeffery Duane Fritz PhD Associate Professor in the Medical School Regional Campuses department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Cell Survival
DNA
Dystrophin
Humans
Injections, Intramuscular
Luciferases
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred ICR
Mice, Neurologic Mutants
Muscles
Muscular Dystrophy, Animal
Plasmids
Recombinant Fusion Proteins
beta-Galactosidase