Faculty Collaboration Database

Alzheimer disease: quantitative analysis of I-123-iodoamphetamine SPECT brain imaging. Radiology 1989 Jul;172(1):183-8

Date

07/01/1989

Pubmed ID

2787034

DOI

10.1148/radiology.172.1.2787034

Scopus ID

2-s2.0-0024365553 (requires institutional sign-in at Scopus site)   51 Citations

Abstract

To enable a more quantitative diagnosis of senile dementia of the Alzheimer type (SDAT), the authors developed and tested a semiautomated method to define regions of interest (ROIs) to be used in quantitating results from single photon emission computed tomography (SPECT) of regional cerebral blood flow performed with N-isopropyl iodine-123-iodoamphetamine. SPECT/IMP imaging was performed in ten patients with probable SDAT and seven healthy subjects. Multiple ROIs were manually and semiautomatically generated, and uptake was quantitated for each ROI. Mean cortical activity was estimated as the average of the mean activity in 24 semiautomatically generated ROIs; mean cerebellar activity was determined from the mean activity in separate ROIs. A ratio of parietal to cerebellar activity less than 0.60 and a ratio of parietal to mean cortical activity less than 0.90 allowed correct categorization of nine of ten and eight of ten patients, respectively, with SDAT and all control subjects. The degree of diminished mental status observed in patients with SDAT correlated with both global and regional changes in IMP uptake.

Author List

Hellman RS, Tikofsky RS, Collier BD, Hoffmann RG, Palmer DW, Glatt SL, Antuono PG, Isitman AT, Papke RA

Author

Piero G. Antuono MD Professor in the Neurology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Aged, 80 and over
Alzheimer Disease
Amphetamines
Brain
Female
Humans
Iodine Radioisotopes
Iofetamine
Male
Middle Aged
Tomography, Emission-Computed