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Using saliva to measure endogenous cortisol in nursing home residents with advanced dementia. Res Nurs Health 2008 Jun;31(3):283-94

Date

01/30/2008

Pubmed ID

18228609

DOI

10.1002/nur.20254

Scopus ID

2-s2.0-46249100997   18 Citations

Abstract

Two research teams determined the feasibility of saliva collection for cortisol measurement in nursing home residents with advanced dementia. Study aims were to: (a) determine if sufficient saliva could be obtained for assay and (b) examine whether cortisol values exhibited range and variability for meaningful interpretation. Useable samples were consistent across sites, suggesting that saliva collection for cortisol assay is a viable method in this setting. Cortisol values showed range and variability. More than half of the residents showed the normal adult pattern of high morning levels decreasing throughout the day. A third of the participants demonstrated an increase in the evening cortisol levels, while the remaining profiles were flat, suggesting hypothalamic-pituitary-adrenal (HPA) dysregulation in this population.

Author List

Woods DL, Kovach CR, Raff H, Joosse L, Basmadjian A, Hegadoren KM

Author

Hershel Raff PhD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Aged
Aged, 80 and over
Analysis of Variance
Circadian Rhythm
Data Collection
Dementia
Feasibility Studies
Female
Geriatric Assessment
Humans
Hydrocortisone
Hypothalamo-Hypophyseal System
Los Angeles
Male
Mental Status Schedule
Nursing Assessment
Nursing Evaluation Research
Nursing Homes
Pituitary-Adrenal System
Saliva
Severity of Illness Index
Specimen Handling
Stress, Psychological
Wisconsin
jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d