Lost unilateral capillary perfusion during nonpulsatile pulmonary circulation: successful recovery by oral sildenafil. Pediatr Cardiol 2012 Feb;33(2):370-4
Date
11/29/2011Pubmed ID
22120513DOI
10.1007/s00246-011-0136-0Scopus ID
2-s2.0-84862297774 (requires institutional sign-in at Scopus site) 2 CitationsAbstract
Good status of pulmonary perfusion is essential for a successful outcome after the Fontan procedure. Increased pulmonary pressure and vascular resistance, small size of the pulmonary arteries, and significant branch stenoses reflect some of the main problems causing failing Fontan circulation. Here we report a child who underwent a staged Fontan procedure with subsequent subtotal loss of the left-sided pulmonary perfusion, although branch stenosis was successfully treated by stent implantation. Oral sildenafil caused restoration of the capillary vascular bed, improved left-sided lung perfusion, and resulted in significant clinical benefit.
Author List
Celik L, Papakostas K, Lentschig M, Hraska V, Nürnberg JHAuthor
Viktor Hraska MD Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
CapillariesChild, Preschool
Fontan Procedure
Heart Defects, Congenital
Humans
Lung
Male
Microcirculation
Piperazines
Pulmonary Circulation
Pulsatile Flow
Purines
Sildenafil Citrate
Sulfones
Vascular Diseases
Vasodilator Agents
