Faculty Collaboration Database

Lifetime probabilities of hematopoietic stem cell transplantation in the U.S. Biol Blood Marrow Transplant 2008 Mar;14(3):316-22

Date

02/16/2008

Pubmed ID

18275898

Pubmed Central ID

PMC2531159

DOI

10.1016/j.bbmt.2007.12.493

Scopus ID

2-s2.0-38949210240 (requires institutional sign-in at Scopus site)   50 Citations

Abstract

Healthcare policies regarding hematopoietic stem cell transplantation (HSCT) must address the need for the procedure as well as the availability of stem cell sources: bone marrow, peripheral blood, or umbilical cord blood (UCB). However, data with respect to the lifetime probability of undergoing HSCT are lacking. This study was undertaken to estimate the latter probability in the United States (U.S.), depending on age, sex, and race. We used data from the Center for International Blood and Marrow Transplant Research, the U.S. Surveillance, Epidemiology and End Results Program, and the U.S. Census Bureau and calculated probabilities as cumulative incidences. Several scenarios were considered: assuming current indications for autologous and allogeneic HSCT, assuming universal donor availability, and assuming broadening of HSCT use in hematologic malignancies. Incidences of diseases treated with HSCT and of HSCTs performed increase with age, rising strongly after age 40. Among individuals older than 40, incidences are higher for men than for women. The lifetime probabilities of undergoing HSCT range from 0.23% to 0.98% under the various scenarios. We conclude that, given current indications, the lifetime probability of undergoing autologous or allogeneic HSCT is much higher than previously reported by others and could rise even higher with increases in donor availability and HSCT applicability.

Author List

Nietfeld JJ, Pasquini MC, Logan BR, Verter F, Horowitz MM

Authors

Mary M. Horowitz MD, MS Professor in the Medicine department at Medical College of Wisconsin
Brent R. Logan PhD Director, Professor in the Institute for Health and Equity department at Medical College of Wisconsin
Marcelo C. Pasquini MD, MS Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Age Factors
Aged
Delivery of Health Care
Female
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells
Humans
Incidence
Life Expectancy
Living Donors
Male
Middle Aged
Neoplasms
Probability
Retrospective Studies
Sex Factors
Transplantation, Autologous
Transplantation, Homologous
United States