Faculty Collaboration Database

Negative 18F-FDG-PET-CT may exclude residual or recurrent disease in anal cancer. Nucl Med Commun 2016 Oct;37(10):1038-45

Date

06/25/2016

Pubmed ID

27341410

DOI

10.1097/MNM.0000000000000560

Scopus ID

2-s2.0-84976274741 (requires institutional sign-in at Scopus site)   14 Citations

Abstract

OBJECTIVES: The incidence of anal cancer is increasing in Western countries. Fluorine-18 fluorodeoxyglucose (F-FDG) PET-computed tomography (CT) is used in the assessment of anal cancer, but its routine use is not established. The aim of this study was to assess the value of F-FDG-PET-CT in staging and post-treatment assessment in anal cancer and to determine its impact on management.

METHODS: This was a retrospective analysis of patients with anal cancer treated at the Sussex Cancer Centre who underwent PET-CT between November 2004 and September 2014. Information was retrieved from patient notes and the local cancer register, and verified by referring consultants in all cases.

RESULTS: A total of 75 PET-CT scans in 52 patients were identified, representing 38.5% of patients diagnosed with anal cancer during this period. There were 24 staging scans and 51 post-treatment scans. Management was altered following 45.8% of staging scans and 56.0% of all scans, mostly changing treatment type or radiotherapy volume. Out of 28 positive post-treatment scans, 71.4% were true positives, 7.1% were false positives and 21.4% showed nonspecific uptake. Of the 23 negative post-treatment scans, all remained disease free at clinical/radiological follow-up (median follow-up 25 months). The sensitivity and specificity of post-treatment PET-CT were 100 and 74%, respectively. Negative predictive and positive predictive values were 100 and 71%, respectively.

CONCLUSION: Evidence is evolving for the use of PET-CT in anal cancer. Because of a high negative predictive value, our series shows that PET-CT can be used in the assessment of treatment response to exclude residual/recurrent disease.

Author List

Teagle AR, Gilbert DC, Jones JR, Burkill GJ, McKinna F, Dizdarevic S

Author

Test W. User test user title in the Anesthesiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Aged, 80 and over
Anus Neoplasms
False Negative Reactions
Female
Fluorodeoxyglucose F18
Humans
Male
Middle Aged
Neoplasm Staging
Neoplasm, Residual
Positron Emission Tomography Computed Tomography
Recurrence
Retrospective Studies