Faculty Collaboration Database

The management of patients with esophageal cancer and coronary artery stenosis undergoing radiotherapy or concurrent chemoradiotherapy: a single-center experience. J BUON 2016;21(2):419-26

Date

06/09/2016

Pubmed ID

27273953

Scopus ID

2-s2.0-84976494692 (requires institutional sign-in at Scopus site)

Abstract

PURPOSE: The incidence of esophageal cancer (EC) patients with coronary artery stenosis presents particular challenges. The aim of this retrospective study was to evaluate the efficiency of management on patients with both diseases treated by radiotherapy (RT) or concurrent chemoradiotherapy (CCRT).

METHODS: Fifty-three patients with both EC and coronary artery stenosis from June 2009 to August 2012 were retrospectively analyzed. The patients received RT or CCRT with coronary artery stenosis management. Cardiac treatments often prescribed included aspirin, β-blockers, statins etc. The adverse effects, overall response rate (ORR), progression-free survival (PFS) and overall survival (OS) were analyzed.

RESULTS: Most of the patients were 40-70 years old. There were 25 patients in the CCRT group and 28 patients in the RT group. The complete response (CR) rate was higher in the patients in the CCRT group than in those in the RT group (48.0 vs 21.4%; p=0.041). The median PFS was 15.9 months in the CCRT group and 11.6 months in the RT group (p=0.025). OS was 22.4 months in the CCRT group and 15.8 months in the RT group (p=0.013). Though adverse effects were less in the RT group, no significance differences in grade 3-4 toxicity were observed.

CONCLUSION: With the appropriate of coronary artery stenosis management, RT and CCRT were both tolerable and effective in EC patients with coronary artery stenosis.

Author List

Luo H, Chen X, Zhang Q, Wang L, Qiao L, Liang N, Xie J, Yu X, Song M, Liu Z, Lv Y, Liu F, Tian Y, Cheng J, Deng G, Zhang J, Li XA, Zhang J

Author

Xiaojian Chen PhD Assistant Professor in the Radiation Oncology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Chemoradiotherapy
China
Coronary Stenosis
Disease-Free Survival
Esophageal Neoplasms
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Proportional Hazards Models
Radiation Dosage
Radiotherapy, Conformal
Retrospective Studies
Risk Factors
Time Factors
Treatment Outcome