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Pathophysiology of Food Allergy. Pediatr Clin North Am 2015 Dec;62(6):1363-75

Date

10/13/2015

Pubmed ID

26456437

DOI

10.1016/j.pcl.2015.07.004

Scopus ID

2-s2.0-84943587106 (requires institutional sign-in at Scopus site)   20 Citations

Abstract

Food allergy is a growing public health problem that is estimated to affect 4% to 8% of children and 5% of adults. In this review, we discuss our current understanding of the pathophysiology of food allergy, from oral tolerance, to sensitization, and lastly the elicitation of an allergic response. As much of the existing evidence for the mechanisms of food allergy is derived from animal models, we include these studies where relevant. In addition, whenever possible, we review similar evidence involved in human disease and provide applications for consideration in clinical practice.

Author List

Pelz BJ, Bryce PJ

Author

Barry Joel Pelz MD Assistant Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Child
Food Hypersensitivity
Gastrointestinal Tract
Humans
Immunization
Immunoglobulin E