Survival after chloroquine ingestion in a child. J Toxicol Clin Toxicol 1988;26(5-6):381-8
Date
01/01/1988Pubmed ID
2848136DOI
10.1080/15563658809167102Scopus ID
2-s2.0-0024253746 (requires institutional sign-in at Scopus site) 9 CitationsAbstract
We report the case of a 17 month old, 14 kg male who ingested 4 grams of chloroquine phosphate. He developed ventricular fibrillation and cardiovascular collapse 1 hour after the ingestion. After resuscitation he was treated with diazepam 2 mg/kg acutely, and 0.25 mg/kg/hour for 4 days with no further cardiac electrophysiologic abnormalities. Gallium-67 scan showed increased radionuclide uptake in heart and renal cortex, but there was no clinical evidence of myocardial or renal dysfunction at the time of the scan. He survived with severe neurologic sequelae from the cardiovascular collapse. He had dynamic peripheral neuropathy and progressive loss of retinal function, as evidence of ongoing chloroquine neurotoxicity.
Author List
Havens PL, Splaingard ML, Bousounis D, Hoffman GMAuthor
George M. Hoffman MD Chief, Professor in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Brain EdemaChloroquine
Coma
Electroencephalography
Evoked Potentials
Humans
Infant
Male
Nervous System Diseases
Peripheral Nervous System Diseases
Reflex, Abnormal
Retinal Diseases
