Faculty Collaboration Database

Impact of Graft-Recipient ABO Compatibility on Outcomes after Umbilical Cord Blood Transplant for Nonmalignant Disease. Biol Blood Marrow Transplant 2016 Nov;22(11):2019-2024

Date

08/09/2016

Pubmed ID

27496217

Pubmed Central ID

PMC5067229

DOI

10.1016/j.bbmt.2016.07.019

Scopus ID

2-s2.0-84992437370 (requires institutional sign-in at Scopus site)   12 Citations

Abstract

Existing literature shows mixed conclusions regarding the impact of ABO incompatibility on outcomes after hematopoietic stem cell transplantation. Because the future for umbilical cord blood (UCB) expansion technologies is bright, we assessed whether this typically overlooked graft characteristic impacted various outcomes after UCB transplantation (UCBT) for nonmalignant disorders (NMDs). A prospectively maintained institutional blood and marrow transplant program database was queried for all patients undergoing first UCBT for NMDs. UCB and recipient ABO compatibility was considered as matched, major mismatched, minor mismatched, or bidirectional mismatched. The impact of ABO incompatibility was assessed on overall survival, graft failure, acute and chronic graft-versus-host disease (GVHD), time to neutrophil and platelet recovery, day 0 to day 100 RBC transfusion burden, and donor hematopoietic chimerism. Through December 2014, 270 patients have undergone first UCBT for various NMDs. In both univariable and multivariable analyses, ABO compatibility status did not appear to impact any outcomes assessed, although a trend toward increased grades III to IV acute GVHD was seen in recipients of major mismatched units. When considering UCBT for treatment of NMDs, ABO compatibility between the donor unit and intended recipient does not appear to be an important consideration in the UCB unit choice.

Author List

Kudek MR, Shanley R, Zantek ND, McKenna DH, Smith AR, Miller WP

Author

Matthew Kudek MD Assistant Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

ABO Blood-Group System
Blood Group Incompatibility
Child
Child, Preschool
Cord Blood Stem Cell Transplantation
Female
Graft Survival
Graft vs Host Disease
Humans
Male
Treatment Outcome