Impact of Graft-Recipient ABO Compatibility on Outcomes after Umbilical Cord Blood Transplant for Nonmalignant Disease. Biol Blood Marrow Transplant 2016 Nov;22(11):2019-2024
Date
08/09/2016Pubmed ID
27496217Pubmed Central ID
PMC5067229DOI
10.1016/j.bbmt.2016.07.019Scopus ID
2-s2.0-84992437370 (requires institutional sign-in at Scopus site) 12 CitationsAbstract
Existing literature shows mixed conclusions regarding the impact of ABO incompatibility on outcomes after hematopoietic stem cell transplantation. Because the future for umbilical cord blood (UCB) expansion technologies is bright, we assessed whether this typically overlooked graft characteristic impacted various outcomes after UCB transplantation (UCBT) for nonmalignant disorders (NMDs). A prospectively maintained institutional blood and marrow transplant program database was queried for all patients undergoing first UCBT for NMDs. UCB and recipient ABO compatibility was considered as matched, major mismatched, minor mismatched, or bidirectional mismatched. The impact of ABO incompatibility was assessed on overall survival, graft failure, acute and chronic graft-versus-host disease (GVHD), time to neutrophil and platelet recovery, day 0 to day 100 RBC transfusion burden, and donor hematopoietic chimerism. Through December 2014, 270 patients have undergone first UCBT for various NMDs. In both univariable and multivariable analyses, ABO compatibility status did not appear to impact any outcomes assessed, although a trend toward increased grades III to IV acute GVHD was seen in recipients of major mismatched units. When considering UCBT for treatment of NMDs, ABO compatibility between the donor unit and intended recipient does not appear to be an important consideration in the UCB unit choice.
Author List
Kudek MR, Shanley R, Zantek ND, McKenna DH, Smith AR, Miller WPAuthor
Matthew Kudek MD Assistant Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
ABO Blood-Group SystemBlood Group Incompatibility
Child
Child, Preschool
Cord Blood Stem Cell Transplantation
Female
Graft Survival
Graft vs Host Disease
Humans
Male
Treatment Outcome