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Potential Hepatotoxicities of Intravenous Fat Emulsions in Infants and Children. Nutr Clin Pract 2016 Oct;31(5):619-28

Date

08/20/2016

Pubmed ID

27540004

DOI

10.1177/0884533616663487

Scopus ID

2-s2.0-84987729823   6 Citations

Abstract

Infants and children who depend on parenteral nutrition are among the most vulnerable to developing potentially devastating intestinal failure-associated liver disease. While the pathogenesis of intestinal failure-associated liver disease remains unclear, evidence for the contribution of fat emulsions to cholestasis and liver injury has rapidly increased in recent years. Data demonstrating the interaction among phytosterols, fatty acids, and antioxidants in cellular pathways that mediate bile flow and hepatic injury have led to the development of newer alternative fat emulsions. This article reviews recent studies that have provided insight into the potential hepatotoxicities of fat emulsions.

Author List

Nghiem-Rao TH

Author

T Hang Nghiem-Rao MD Associate Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Antioxidants
Child
Cholestasis
Fat Emulsions, Intravenous
Fatty Acids
Gastrointestinal Diseases
Humans
Infant
Liver Failure
Parenteral Nutrition
Phytosterols