Faculty Collaboration Database

Clinical characteristics and in hospital outcomes of heart transplant recipients with allograft vasculopathy undergoing percutaneous coronary intervention: Insights from the National Cardiovascular Data Registry. Am Heart J 2015 Dec;170(6):1086-91

Date

12/19/2015

Pubmed ID

26678629

DOI

10.1016/j.ahj.2015.09.021

Scopus ID

2-s2.0-84949517867 (requires institutional sign-in at Scopus site)   12 Citations

Abstract

BACKGROUND: Cardiac allograft vasculopathy is a major cause of morbidity and mortality following heart transplantation. Large multicenter studies evaluating the clinical characteristics and inhospital outcomes of heart transplant recipients undergoing percutaneous coronary intervention (PCI) are lacking.

OBJECTIVE: To evaluate the clinical characteristics, treatment patterns and inhospital outcomes of heart transplant recipients undergoing PCI compared to general population.

METHODS: We analyzed 1,897,328 patients from the National Cardiovascular Data Registry CathPCI registry who underwent PCI of at least 1 native vessel between July 2009 and December 2013 from 1,477 centers, of which 542 patients (0.03%) were heart transplant recipients. Clinical characteristics were evaluated and, after 1:4 propensity matching, inhospital outcomes were compared between 538 heart transplant patients and 2,128 non-transplant patients.

RESULTS: Transplant recipients undergoing PCI had a higher prevalence of diabetes, dyslipidemia and peripheral vascular disease; lower prevalence of angina, acute coronary syndrome, abnormal noninvasive functional study, and type C coronary lesions compared to the non-transplant PCI population. After propensity matching, all-cause inhospital mortality was similar between transplant and non-transplant groups (1.3% vs 1.0%; OR, 1.21; 95% CI, 0.54-2.67).

CONCLUSION: This is the largest series to date outlining the characteristics of heart transplant recipients undergoing PCI. Similar inhospital outcomes were noted in heart transplant recipients compared to the general population. Further studies evaluating long-term outcomes are warranted.

Author List

Dasari TW, Saucedo JF, Krim S, Alkhouli M, Fonarow GC, Alvarez R, Ibrahim H, Dai D, Wang TY, Costa M, Lindenfeld J, Messenger JC

Author

Jorge Saucedo MD Chief, Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Allografts
Comorbidity
Coronary Angiography
Coronary Artery Disease
Female
Heart Transplantation
Humans
Long Term Adverse Effects
Male
Middle Aged
Percutaneous Coronary Intervention
Postoperative Complications
Registries
United States
Vascular Diseases