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Methods for generating paired competing risks data. Comput Methods Programs Biomed 2016 Oct;135:199-207

Date

09/03/2016

Pubmed ID

27586491

Pubmed Central ID

PMC5036582

DOI

10.1016/j.cmpb.2016.07.027

Scopus ID

2-s2.0-84981156282 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

BACKGROUND AND OBJECTIVES: Clustered competing risks data arise often in genetic studies, multicenter investigations, and matched-pairs studies. In the last two decades, major advances in competing risks theory had been made. Many new statistical methods need to be evaluated via simulation studies. Some mechanisms for simulating clustered competing risks data have been considered in the literature. However, most of them produce data where the strength of the dependence between individuals within a cluster is not clear. In this article, we aim to examine various techniques for generating bivariate competing risks data.

METHODS: Theoretical framework for simulating dependent competing risks data using latent failure time approach, multistate models, and shared frailty models is described. The steps needed to implement each method are outlined. Properties of each technique are discussed and standard measures of association are provided in order to assess the degree of dependence in simulated paired competing risks data.

RESULTS AND CONCLUSIONS: In addition to describing a variety of techniques to generate dependent competing risks data, the cross-hazard ratios from multiple scenarios for each method are computed. The cross-hazard ratios provide a means to compare the level of dependence of the generated data across methods. This acts as a guide for researchers to select an approach and the parameters needed to achieve the desired degree of dependence for their simulation studies.

Author List

Brazauskas R, Le-Rademacher J

Author

Ruta Brazauskas PhD Associate Professor in the Data Science Institute department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Algorithms
Computer Simulation
Humans
Risk Factors