Secondary metabolites from three Florida sponges with antidepressant activity. J Nat Prod 2008 Feb;71(2):186-9
Date
01/26/2008Pubmed ID
18217716Pubmed Central ID
PMC4918908DOI
10.1021/np070371uScopus ID
2-s2.0-40549109549 (requires institutional sign-in at Scopus site) 69 CitationsAbstract
Brominated indole alkaloids are a common class of metabolites reported from sponges of the order Verongida. Herein we report the isolation, structure determination, and activity of metabolites from three Florida sponges, namely, Verongula rigida (order Verongida, family Aplysinidae), Smenospongia aurea, and S. cerebriformis (order Dictyoceratida, family Thorectidae). All three species were investigated chemically, revealing similarities in secondary metabolites. Brominated compounds, as well as sesquiterpene quinones and hydroquinones, were identified from both V. rigida and S. aurea despite their apparent taxonomic differences at the ordinal level. Similar metabolites found in these distinct sponge species of two different genera provide evidence for a microbial origin of the metabolites. Isolated compounds were evaluated in the Porsolt forced swim test (FST) and the chick anxiety-depression continuum model. Among the isolated compounds, 5,6-dibromo- N,N-dimethyltryptamine ( 1) exhibited significant antidepressant-like action in the rodent FST model, while 5-bromo- N,N-dimethyltryptamine ( 2) caused significant reduction of locomotor activity indicative of a potential sedative action. The current study provides ample evidence that marine natural products with the diversity of brominated marine alkaloids will provide potential leads for antidepressant and anxiolytic drugs.
Author List
Kochanowska AJ, Rao KV, Childress S, El-Alfy A, Matsumoto RR, Kelly M, Stewart GS, Sufka KJ, Hamann MTAuthor
Abir El-Alfy PhD Assistant Dean, Professor in the School of Pharmacy Administration department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAnti-Anxiety Agents
Antidepressive Agents
Chickens
Disease Models, Animal
Dose-Response Relationship, Drug
Florida
Hydrocarbons, Brominated
Indole Alkaloids
Marine Biology
Mice
Molecular Structure
N,N-Dimethyltryptamine
Porifera
