Faculty Collaboration Database

A study of 13 patients with gastric tube in place after esophageal resection: use of omeprazole to decrease gastric acidity and volume. J Clin Anesth 2001 Aug;13(5):370-3

Date

08/11/2001

Pubmed ID

11498319

DOI

10.1016/s0952-8180(01)00289-6

Scopus ID

2-s2.0-0034906181 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

STUDY OBJECTIVE: To investigate whether oral omeprazole 20 mg decreases the risk of aspiration pneumonia in patients with gastric tube reconstruction.

DESIGN: Consecutive study.

SETTING: Operation room of cancer center.

PATIENTS: Thirteen patients with gastric tube reconstruction for esophageal cancer.

INTERVENTIONS: Oral omeprazole 20 mg was given the night before surgery. A rapid-sequence induction with cricoid pressure was employed for induction of anesthesia. After tracheal intubation, a nasogastric catheter was inserted into the gastric tube and the contents were aspirated.

MEASUREMENTS AND MAIN RESULTS: The pH and volume of the gastric contents were measured. The pH and volume of the gastric tube contents were 4.5 +/- 1.6 (range from 2.5 to 7.0) and 9.5 +/- 10.2 mL (range from 0 to 30 mL), respectively. Food residue was recognized in nine patients. There was no patient with a pH below 2.5 and a volume of 25 mL or greater.

CONCLUSIONS: Omeprazole 20 mg decreased the acidity and volume of the gastric tube contents and reduced the risk of aspiration pneumonia in patients with a gastric tube in place.

Author List

Yamanaka Y, Mammoto T, Kita T, Kishi Y

Author

Tadanori Mammoto MD, PhD Associate Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Anti-Ulcer Agents
Esophagus
Female
Gastric Acid
Humans
Hydrogen-Ion Concentration
Intubation, Gastrointestinal
Male
Middle Aged
Omeprazole
Pneumonia, Aspiration
Stomach