Faculty Collaboration Database

Antiarrhythmic action of rilmenidine on adrenaline-induced arrhythmia via central imidazoline receptors in halothane-anaesthetized dogs. Br J Pharmacol 1996 Apr;117(8):1744-8

Date

04/01/1996

Pubmed ID

8732285

Pubmed Central ID

PMC1909557

DOI

10.1111/j.1476-5381.1996.tb15348.x

Scopus ID

2-s2.0-0029881209 (requires institutional sign-in at Scopus site)   24 Citations

Abstract

1. To elucidate the role of central imidazoline receptors in the genesis of adrenaline-induced arrhythmias under halothane anaesthesia, we investigated the effects of rilmenidine, a selective agonist at imidazoline receptors, on this type of arrhythmia in dogs. Rilmenidine (1, 3, 10 micrograms kg-1, i.v.) did not affect basal haemodynamic parameters (heart rate and blood pressure), but dose-dependently inhibited adrenaline-induced arrhythmias under halothane anaesthesia. 2. Although, rilmenidine has a weak affinity for alpha(2)-adrenoceptors, pretreatment with idazoxan (10 micrograms kg-1, intracisternally i.c.), an imidazoline receptor antagonist which has also alpha(2)-adrenoceptor blocking potency, blocked the antiarrhythmic effect of rilmenidine (10 micrograms kg-1, i.v.). In contrast, pretreatment with rauwolscine (20 micrograms kg-1, i.c.), a classical alpha(2)-adrenoceptor antagonist with little affinity for imidazoline receptors, did not affect the effect of rilmenidine (10 micrograms kg-1, i.v.). Furthermore, bilateral vagotomy completely blocked the antiarrhythmic action of rilmenidine (10 micrograms kg-1, i.v.). 3. It is suggested that the antiarrhythmic action of rilmenidine is due to the activation of central imidazoline receptors and that vagal tone is critical for this action of rilmenidine.

Author List

Mammoto T, Kamibayashi T, Hayashi Y, Yamatodani A, Takada K, Yoshiya I

Author

Tadanori Mammoto MD, PhD Associate Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adrenergic alpha-Agonists
Adrenergic alpha-Antagonists
Analysis of Variance
Anesthetics, Inhalation
Animals
Arrhythmias, Cardiac
Blood Pressure
Dogs
Epinephrine
Female
Halothane
Heart Rate
Idazoxan
Imidazoline Receptors
Male
Oxazoles
Receptors, Drug
Yohimbine